The roots of Lowell Methodist Church reach back to the early 1840s, when worshippers first gathered in a simple brush arbor. This was later replaced by a log church, which was destroyed by fire around 1865. For the next three decades, the community had no dedicated place of worship, so local Methodists and Baptists built the Union Church at Midway, sharing it for services until 1898. The present Lowell Methodist Church was completed in 1900, constructed from virgin pine. Inside, the original pews, pulpit, and altar rail remain, offering a tangible link to the past. The community of Lowell was first settled around 1820 along the falls of Pataula Creek, whose waters powered a sawmill, cotton gin, and grist mill. Once known as Garfield, the town’s church originally stood along Pataula Creek and now sits near the shore of Lake Walter F. George, created in 1952 when a dam was built at the convergence of the Chattahoochee and Flint Rivers.

The land for the church was first donated by Hartwell Jones Wash and later purchased by W. T. Credille, Sr., who, with his wife Ada Elizabeth Standley, deeded it to the church in 1900. The Credille and Wash families have remained active in the congregation for four generations. Early members included Lewis Hartley, Edgar Redding, E. G. Owens, J. I. Crapps, R. L. Burnett, W. E. Puckett, Erasmus King, and members of the Standley family, many of whom rest in the cemetery beside the church.

Clay County, where Lowell is located, was established in 1854 from parts of Randolph and Early counties. The county seat, Fort Gaines, was founded in 1816 around a fort built by General Edmund Pendleton Gaines under orders from Andrew Jackson during the Creek Indian wars. The fort also served as a Confederate defense post in 1863.

Next to the church stands a former schoolhouse, built around 1890, which now serves as the fellowship hall. The school once taught 10–25 students, with its last class held in 1921. Today, Lowell Methodist remains an active congregation, holding Sunday services at 9:30 a.m., continuing its long tradition of faith and community in southwest Georgia.